The effects of a treatment combination of anti-VEGF injectio
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The aim of the article was to examine the curative effect of vitreous injection with ranibizumab, laser coagulation and cryotherapy in treating stage 3 Coats’ disease with exudative retinal detachment. Coats’ disease commonly occurs in young children. Therefore, it is very difficult to detect in the early stage, and patients often present with higher than stage 3 when diagnosed. For these patients, treatment with retinal laser photocoagulation and cryotherapy alone is not ideal. In recent years, intravitreal injection of anti-vascular endothelial growth factor drugs has been widely used in age-related macular degeneration, diabetic retinopathy, macular edema, retinal central vein obstruction macular edema and other diseases.

Studies have also shown that Coats’ patients have high expression levels of intravascular vascular endothelial growth factor (VEGF) [3–6]. These findings suggest that intravitreal injection of anti-VEGF drugs may help to reduce the VEGF concentration, promote subretinal fluid and exudate absorption and stabilize against abnormal proliferation or degradation of vasculature. Additionally, a few studies have investigated anti-VEGF drug treatment in Coats’ disease and achieved good efficacy in the cases reported [3–6], although the overall sample size has been small. We retrospectively analyzed the use of anti-VEGF drugs combined with other methods to treat Coats’ disease with the aim of exploring the use, safety, and effectiveness of anti-VEGF drugs in the treatment of Coats’ disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440965/
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