The glaucoma intensive treatment study: Perimetric rate of g
A Study was conducted to determine the perimetric rate of glaucoma progression in the ongoing Glaucoma Intensive Treatment Study (GITS) after 3 years of follow-up.

The participants of this study were treatment-naive patients with newly diagnosed OAG, aged 46–78 years, with early to moderate glaucomatous visual field loss scheduled to be followed for 5 years within the study.

Patients were randomized to initial treatment with either topical monotherapy or with an intensive approach using drugs from three different classes, plus 360° laser trabeculoplasty. Changes in treatment were allowed. Standard automated perimetry and tonometry were performed and side-effects documented.

--A total of 242 patients were randomized. After 3 years of follow-up, 8 patients were lost to follow-up, 6 of whom were deceased.

--The median untreated baseline intraocular pressure (IOP) was 24 mmHg in both arms.

--The median IOP was almost constant over the 3 years of follow-up: -17 mmHg in the mono-arm and -14 mmHg in the multi-treatment arm.

--Treatment was intensified in 42% of the mono-treated patients and in 7% of the multi-treated patients.

--Treatment was reduced in 13% of the multi-treated patients. The median perimetric rate of progression was ?0.5%/year in the mono-treated group and ?0.1%/year in the multi-treated group.

Conclusively, the rate of illness development in the multi-treated individuals was considerably slower than in the mono-treated patients. More research will be done to see if the difference persists over time.