The outstanding diagnosis- JETS
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Altman and Robin first described platypnea-orthodeoxia syndrome (POS) in 1969, although this physiological phenomenon had been originally described in 1956. POS results from intra-cardiac, intra-pulmonary or intrahepatic arteriovenous shunts and ventilation-perfusion mismatch. We report this syndrome in a 66-year-old Caucasian female with an 80 pack-year smoking history 7 months after right pneumonectomy for hilar squamous cell carcinoma. One-month post-pneumonectomy, she noticed gradual onset dyspnea, more pronounced on standing upright and with activity, mandating her to use 3 L of oxygen which she did not use before surgery. Preoperative pulmonary function tests showed forced expiratory volume in 1 s (FEV 1 ) of 1.69 L (79% predicted) and diffusing capacity for carbon monoxide (DLCO) of 66% predicted...

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