The prognostic value of IL-8 for the death of severe or crit
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Inflammation has been believed to contribute to COVID-19. Risk factors for death of COVID-19 pneumonia have not yet been well established.

In this retrospective cohort study, researchers included the deceased patients in COVID-19 specialized ICU with laboratory-confirmed COVID-19 from Guanggu hospital area of Tongji Hospital. Demographic, clinical, laboratory, and outcome data were extracted from electronic medical records using a standard data collection form. They used Spearman rank correlation and Cox regression analysis to explore the risk factors associated with in-hospital death, especially the association between inflammatory cytokines and death.

A total of 205 severe/critical COVID-19 pneumonia patients were admitted in the COVID-19 specialized ICU and 75 deceased patients were included in the final analysis. The median age of the deceasing patients was 70 years (IQR 65–79). The common symptoms were fever (78.9%), cough (70.4%), and expectoration (39.4%). The BNP and CRP levels were far beyond the normal reference range. In the Spearman rank correlation analysis, IL-8 was found to be significantly associated with the time from onset to death and that from admission to death. Cox regression showed after adjusting age and sex, IL-8 levels were still significantly associated with the time from onset to death and that from admission to death.

IL-8 levels were associated with in-hospital death in severe/critical COVID-19 patients, which could help clinicians to identify patients with high risk of death at an early stage.

Source: https://journals.lww.com/md-journal/Fulltext/2021/03190/The_prognostic_value_of_IL_8_for_the_death_of.5.aspx
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