The role of vitamin D in the prevention of COVID-19 and mort
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WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose a hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D for 20 European countries and morbidity and mortality caused by COVID-19 were acquired. Negative correlations between mean levels of vitamin D in each country and the number of COVID-19 cases/1 M and mortality/1 M were observed. Vitamin D levels are severely low in the aging population.

The pathology of COVID-19 involves a complex interaction between the SARS-CoV2 and the body immune system. Calcitriol (1,25-dihydroxyvitamin D3) exerts pronounced impacts on ACE2/Ang(1–7)/MasR axis with enhanced expression of ACE2. ACE2 is the host cell receptor responsible for mediating infection by SARS-CoV-2. From this perspective it might be apparent that the risk of infection can be higher. However, vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection.

In conclusion, significant crude relationships between vitamin D levels and the number of COVID-19 cases and especially the mortality caused by this infection are found. The most vulnerable group of the population for COVID-19, the aging population, is also the one that has the most deficit Vitamin D levels. Vitamin D has already been shown to protect against acute respiratory infections and it was shown to be safe. It should be advisable to perform dedicated studies about vitamin D levels in COVID-19 patients with different degrees of disease severity.

Dr. T●●●●z H●●●●●●i and 25 others like this28 shares
Dr. V●●●●●●j D●●●i
Dr. V●●●●●●j D●●●i Legal Medicine
I believe that the study of association of vitamin D levels and any virus including COVID19 is incomplete without studying the association between virus survival in temperate climates as against in tropical climates where vitamin D levels are expected to be different.
May 9, 2020Like4