The severity and atypical presentations of COVID-19 infectio
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Emergence of 2019-nCoV attracted global attention and WHO declared COVID-19 a public health emergency of international concern. Therefore researchers aimed to explore the severity and atypical manifestations of COVID-19 among children. This is an observational cohort study conducted on 398 children with confirmed COVID-19 by using a real-time reverse transcriptase-polymerase chain reaction assay for detection of 2019-nCoV nucleic acid during the period from March to November 2020. Patients were subdivided regarding the severity of COVID-19 presentation into Group I (Non-severe COVID-19) was admitted into wards and Group II (Severe COVID-19) admitted into the PICU. Most children had a non-severe type of COVID-19 and children with severe type had higher levels of D-dimer, hypoxia, shock, and mechanical ventilation.

Non- severe cases were 295cases (74.1%) and 103cases (25.9%) of severe cases. There was a significant difference between age groups of the affected children with a median (0–15 years). Boys (52%) are more affected than girls (48%) with significant differences. 68.6%of confirmed cases had a contact history to family members infected with COVID-19. 41.7% of severe patients needed mechanical ventilation. Death of 20.4% of severe cases. In COVID-19 patients, fever, headache, fatigue, and shock were the most prominent presentations. 3.5% of children were manifested with atypical presentations; 1.25% manifested by pictures of acute pancreatitis, 1.25% presented by manifestations of deep venous thrombosis and 1.0% had multisystem inflammatory syndrome (MIS-C). Multivariate regression analysis showed that COVID-19 severity in children was significantly higher among children with higher levels of D-dimer, hypoxia, shock, and mechanical ventilation.

Source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992820/
Like
Comment
Share