Thigh Muscle Fat Predicts Risk of Developing Heart Failure
A higher level of intramuscular fat infiltration in the thighs was associated with a higher risk of developing heart failure. The association was independent of other cardiometabolic risk factors and measures of adiposity such as body mass index. They used data from 2399 individuals aged 70 to 79 years without heart failure at baseline who participated in the Health ABC (Health, Aging and Body Composition) study. Measures of intramuscular and intermuscular fat in the thigh were determined by computed tomography, and the participants were followed for an average of 12 years. Individuals in the highest tertile of intramuscular fat had a 34% increased risk of developing heart failure compared with those in the lowest tertile.