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Researchers at Dartmouth have identified novel gene-smoking interactions in lung cancer development, providing new candidate biomarkers and further closing the gap between heritability and lung cancer.
In the study, three novel SNPs (single-nucleotide polymorphisms), or variations in DNA that underlie body's susceptibility to developing a disease, were identified in the interaction analysis which provide potential candidate biomarkers for lung cancer risk screening and intervention. These three SNPs can be potential biomarkers used to improve the precision to which researchers can categorize an individual's risk of lung cancer disease by smoking behavior, which are helpful for individualized prognosis and prediction of the treatment plan.
The team's findings, "Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in the Caucasian population," have been published in Carcinogenesis...
https://www.sciencedaily.com/releases/2017/10/171028081456.htm
In the study, three novel SNPs (single-nucleotide polymorphisms), or variations in DNA that underlie body's susceptibility to developing a disease, were identified in the interaction analysis which provide potential candidate biomarkers for lung cancer risk screening and intervention. These three SNPs can be potential biomarkers used to improve the precision to which researchers can categorize an individual's risk of lung cancer disease by smoking behavior, which are helpful for individualized prognosis and prediction of the treatment plan.
The team's findings, "Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in the Caucasian population," have been published in Carcinogenesis...
https://www.sciencedaily.com/releases/2017/10/171028081456.htm
Three new lung cancer genetic biomarkers identified: In a large genome-wide association analysis, researchers identify novel gene-smoking interactions in lung cancer development, providing new candidate biomarkers and further closing the gap between heritability and lung cancer
SNPs (single-nucleotide polymorphisms) are variations in our DNA that determine our susceptibility to developing some diseases. Using the largest genome-wide SNP-smoking interaction analysis reported
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