Throat Spray, Oral Drug For Malaria-Arthritis Effective In R
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An antiseptic throat spray and an oral drug usually prescribed to treat malaria and arthritis have been found to effectively reduce the spread of COVID-19 in high-transmission settings, researchers have found. The findings were made based on a large-scale clinical trial conducted last May.

During the six-week trial, workers were given a povidone-iodine throat spray, which can be bought off the counter, and oral hydroxychloroquine, which requires a prescription. Both were found to reduce the incidence of coronavirus infection, according to the study. The two drugs were chosen because they are easily available and they protect the throat, the “key entry" for viruses.

A total of 3,037 asymptomatic healthy men aged between 21 and 60 were involved in the trial on a voluntary basis. Participants were excluded if they had any symptoms of respiratory illnesses like fever, cough or loss of smell a month before the start of the trial. Those who had previous COVID-19 infection were also not included.

The povidone-iodine throat spray had to be used thrice a day. After six weeks, more than half of the participants had tested positive for COVID-19. But among those who used the throat spray, only 46 percent contracted the disease. This is compared to 49 percent among those who took hydroxychloroquine and 70 percent who took vitamin C.

It was concluded that povidone-iodine throat spray was associated with a statistically significant reduction in infection by an absolute risk of reduction of 24 percent while oral hydroxychloroquine was associated with a statistically significant reduction in infection by an absolute risk of reduction of 21 percent.

Source:
https://www.ijidonline.com/article/S1201-9712(21)00345-3/fulltext
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