Thyroid angiosarcoma
Thyroid angiosarcoma is a very rare malignancy that is mostly seen in the elderly Alpine regions, related to the high prevalence of iodine-deficient goiter. It is a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small bowel, and large bowel. Metastatic disease is associated with a poor prognosis and limits the mean survival time to a few months after diagnosis and surgical treatment. The first diagnostic challenge is to rule out an angiomatoid anaplastic carcinoma, using a large panel of antibodies. The second challenge is to specify whether it is a primary or metastatic angiosarcoma especially when other sites are involved, based on clinical and epidemiological criteria.

Source: https://www.sciencedirect.com/science/article/pii/S2210261222006046?dgcid=rss_sd_all
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