Thyroid eye disease present in 40% of people with Graves’ di
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Two of five people with Graves’ disease worldwide have thyroid eye disease, with higher rates among Asian populations vs. other ethnicities, according to a meta-analysis published in Clinical Endocrinology.

Researchers searched two electronic databases, Medline and Embase, for articles from inception through April of 2020. The analysis included 57 articles (n = 26,804) from various regions that described the prevalence of thyroid eye disease, its signs and symptoms, and practice and management. Data extracted from the articles included the study’s country of origin, patient characteristics, the proportion of thyroid eye disease, classification guidelines and ophthalmic signs and symptoms.

Based on 33 articles, the pooled prevalence of thyroid eye disease among 22,384 people with Graves’ disease was 40% (95%). The prevalence was similar when articles with a high risk for bias were removed (38%) and when studies using only the NOSPECS classification of Graves’ disease were removed (40%). Researchers broke down the prevalence of thyroid eye disease by continent and ethnicity. The pooled prevalence of thyroid eye disease was 44% in Asia (95%), 38% in Europe (95%), and 27% in North America (095%). People of Asian ethnicities had a higher prevalence of thyroid eye disease (45%) than white people (37%). While there was no significant difference reported between the two groups, researchers said another study should focus on why Asians appear to be more susceptible to thyroid eye disease. “This slight difference in the prevalence of thyroid eye disease among Asians could be due to genetic predispositions, biochemical factors, or the high prevalence of smokers,” researchers wrote.

Lid retraction (57%) and proptosis (57%) were the most common clinical manifestation of thyroid eye disease, followed by diplopia (36%) and ocular hypertension (13%). Researchers noted 22 studies in the meta-analysis did not follow any guidelines for diagnosing thyroid eye disease. They urged practitioners to create standard reporting for the disease to allow for a better understanding of the clinical burden and to provide better resources for patients and providers.s.”

Source:https://www.healio.com/news/endocrinology/20200903/thyroid-eye-disease-present-in-40-of-people-with-graves-disease
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