Time in Range in Relation to All-Cause and Cardiovascular Mo
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There is growing evidence linking time in range (TIR), an emerging metric for assessing glycemic control, to diabetes-related outcomes. Researchers aimed to investigate the association between TIR and mortality in patients with type 2 diabetes.

A total of 6,225 adult patients with type 2 diabetes were included. TIR was measured with continuous glucose monitoring at baseline, and the participants were stratified into four groups by TIR: greater than 85%, 71–85%, 51–70%, and less than 50%. Cox proportional hazards regression models were used to estimate the association between different levels of TIR and the risks of all-cause and cardiovascular disease (CVD) mortality.

Results:
-- The mean age of the participants was 61.7 years at baseline.

--During a median follow-up of 6.9 years, 838 deaths were identified, 287 of which were due to CVD.

-- The multivariable-adjusted hazard ratios associated with different levels of TIR (more than 85% [reference group], 71–85%, 51–70%, and less than 50%) were 1.00, 1.23, 1.30, and 1.83 for all-cause mortality and 1.00, 1.35, 1.47, and 1.85 for CVD mortality, respectively.

Conclusively, the current study indicated an association of lower TIR with an increased risk of all-cause and CVD mortality among patients tith type 2 diabetes, supporting the validity of TIR as a surrogate marker of long-term adverse clinical outcomes.

Source: https://care.diabetesjournals.org/content/early/2020/10/23/dc20-1862?rss=1
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