Tissue, scaffold technologies provide new options for breast
New technology on a regenerative tissue filler from innovators may help improve tissue restoration outcomes for people with breast cancer and other diseases or traumatic injuries.

This is a first-of-a-kind, in situ scaffold-forming collagen. When applied as a filler for soft tissue defects and voids, it shows promise for accelerating and improving tissue restoration outcomes. The team's work is published in Scientific Reports.

The regenerative tissue filler, when applied to breast tissue voids, such as those associated with breast-conserving surgery, restored breast shape and consistency and supported new breast tissue formation over time, including mammary glands, ducts, and adipose tissue. The filler also helped avoid wound contraction and scar formation, which can be painful for patients and contribute to breast deformities.

This filler represents a highly purified liquid collagen protein, that when brought to physiologic conditions by mixing with a proprietary buffer, can be applied to tissue voids. The liquid collagen conforms to patient-specific void geometries and then undergoes a self-assembly reaction to form fibrillar collagen scaffold-like those that make up the body's tissues.

This scaffold has soft tissue consistency and persists, where it induces a regenerative healing response.

"This tissue filler represents the first planned medical product developed using our innovative collagen polymer technology," the author said. "This collagen polymer supports custom fabrication of a broad range of collagen materials for various applications including tissue restoration, therapeutic cell, and drug delivery, or enhancement of tissue-implantable devices interfaces."

Source: https://doi.org/10.1038/s41598-021-81771-x
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