Figure 1: Algorithm: Guidelines for Neonatal PRBC Transfusion for Anemia of Prematurity (AOP). At first, please exclude conditions such as neonatal sepsis, apnea of prematurity, and acute hemorrhage, by clinical history, examination and screening investigations. Then check your institutional guidelines. If unavailable only, follow this algorithm. Evidence is limited for this algorithm (level 3-based on cross sectional studies).