Topical erythropoietin on non-surgical treatment of periodon
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Topical erythropoietin along with scaling and root planning can improve inflammation and clinical attachment loss, according to research published the BMC Oral Health.

The purpose of periodontal treatments is to reduce inflammation, restore gingival health and clinical attachment level gain by controlling microbial plaque formation and other etiological factors. Researchers evaluated the effect of erythropoietin (EPO) on the improvement of periodontitis after the phase I treatment.

This study was conducted on 30 patients with stage III periodontitis who had at least two bilateral teeth with CAL of ≥5 mm and PPD ≥6 mm at ≥2 non-adjacent teeth and bleeding on probing. After oral hygiene instruction and scaling and root planning (SRP), EPO gel containing a solution of 4000 units was applied deeply in the test group and placebo gel was deeply administered in the control pockets (5 times, every other day). The clinical parameters of the plaque index (PI), gingival index (GI), clinical attachment level (CAL), probing depth (PD), and bleeding index (BI) were measured at baseline and after three months of follow up.

--All clinical variables improved after treatment in both groups. The BI and GI scores showed statistically more reduction in the test group.

--The CAL decreased from 5.1±4.1 to 3.40±2.71 mm; and 5.67±4.32 to 4.33±3.19 mm in the test and control group, respectively.

--After the treatment, there was a significantly greater reduction in CAL and also PD values in the test group.

Conclusively, local application of EPO gel in adjunct to SRP can improve clinical inflammation and CAL gain in periodontitis.

Source: https://doi.org/10.1186/s12903-021-01607-y
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