Topical treatment of diabetic retinopathy, finds Study
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Diabetic retinopathy (DR) is the most common microvascular complication in diabetes and may cause severe visual impairment. The aim of the present review was to investigate whether changes of DR might be influenced by topical treatment with eye drops.

This systematic review included both randomized and non-randomized human clinical studies on the subject. Reference lists as well as first authors were screened for the inclusion of additional studies. Potential bias of the randomized studies was assessed using the Cochrane Risk of Bias tool. 19 studies suitable for inclusion were identified. 7 studies were randomized trials. These examined 11 different pharmacological groups of drugs in DR.

--A favourable effect of corticosteroid eye drops in diabetic macular oedema (DMO) was reported in 4 studies, and another study reported a positive trend.

--Eye drops with non-steroidal anti-inflammatory drugs were also reported to have a favourable effect in DMO, but not in non-center involving DMO.

--Application of neuroprotective agents was found effective in patients with pre-existing neurodegeneration in three studies.

--The remaining studies of DMO and DR were heterogeneous in both designs and results. Studies on treatment of DR with topical eye drops vary with regards to patient population, interventional drugs, study design, and outcome measures.

Treatment of DR with eye drops was found effective in the aforementioned cases.

Source: https://onlinelibrary.wiley.com/doi/10.1111/aos.14912?af=R
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