Trace elements and oxidative stress status in patients with
Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role. The present study has indicated that there are alterations in serum trace element levels and an increase in inflammation and oxidative stress in psoriasis patients. Supplementation of Se and Zn, and anti-oxidant therapy could positively influence the clinical course of the disease. However, more comprehensive studies are required to explain the role of these findings in etiopathogenesis of psoriasis.

A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants.

IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX, and CRP levels were found to be significantly higher; Se, Zn, and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe, and MPO levels.