Traditional CV risk factors may be tied to future cancer ris
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CV risk factors such as age, sex, smoking status, 10-year atherosclerotic CVD risk and certain biomarkers were independently associated with risk for future cancer, according to data published in JACC: CardioOncology.

The extent to which co-occurrence of cardiovascular disease (CVD) and cancer is due to shared risk factors or other mechanisms is unknown.

This study investigated the association of standard CVD risk factors, CVD biomarkers, pre-existing CVD, and ideal cardiovascular (CV) health metrics with the development of future cancer.

This study prospectively followed Framingham Heart Study and PREVEND (Prevention of Renal and Vascular End-Stage Disease) study participants free of cancer at baseline and ascertained histology-proven cancer. This study assessed the association of baseline CV risk factors, 10-year atherosclerotic (ASCVD) risk score, established CVD biomarkers, prevalent CVD, and the American Heart Association (AHA) Life’s Simple 7 CV health score with incident cancer using multivariable Cox models. Analyses of interim CVD events with incident cancer used time-dependent covariates.

-- Among 20,305 participants (mean age 50 ± 14 years; 54% women), 2,548 incident cancer cases occurred over a median follow-up of 15.0 years (quartile 1 to 3: 13.3 to 15.0 years).

-- Traditional CVD risk factors, including age, sex, and smoking status, were independently associated with cancer.

-- Estimated 10-year ASCVD risk was also associated with future cancer.

-- The study found that natriuretic peptides were associated with incident cancer but not high-sensitivity troponin.

-- Prevalent CVD and the development of interim CV events were not associated with higher risk of subsequent cancer.

-- However, ideal CV health was associated with lower future cancer risk.

Conclusively, CVD risk, as captured by traditional CVD risk factors, 10-year ASCVD risk score, and natriuretic peptide concentrations are associated with increased risk of future cancer. Conversely, a heart healthy lifestyle is associated with a lower risk of future cancer. These data suggest that the association between CVD and future cancer is attributable to shared risk factors.