Tranexamic Acid Administration is Effective in Postoperative
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Previous studies have shown that systemic tranexamic acid reduces bleeding during soft tissue surgeries and reduces postoperative ecchymosis and edema experienced by surgical patients. A Study was conducted to evaluate the effect of postoperative tranexamic acid administration on the reduction of ecchymosis and edema after lipoma surgery.

A total of 40 patients who underwent lipoma excision were included in the comparative analysis. In the tranexamic acid group (n = 20), 1 g of tranexamic acid was administered daily for 5 consecutive postoperative days. Tranexamic acid was not administered to the control group (n = 20). The severity of ecchymosis and edema at the first visit after surgery was rated on a 4-point scale by 2 blinded dermatologists.

Results:
--The mean interval of the initial visit after surgery was 1.1 ± 0.5 (range: 1–4) days.
--Mean ecchymosis scores were significantly lower in the tranexamic acid group (0.5 ± 0.8) than in the control group (1.2 ± 1.0).
--No statistical difference was seen in mean edema scores between groups (0.5 ± 0.6 in tranexamic acid vs 0.7 ± 0.8 in control).

Conclusively, it was observed that postoperative administration of tranexamic acid significantly decreased ecchymosis in lipoma excision.

Source: https://journals.lww.com/dermatologicsurgery/Abstract/2021/03000/Effect_of_Tranexamic_Acid_Administration_on.10.aspx
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