Treatable Leukoencephalopathy in a Patient with Hypophosphat
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Hypophosphatemia is a critical condition that ultimately reduces a primary energy source, ATP. Thus, it affects virtually all organs and tissues. In nervous systems, hypophosphatemia causes irritability, decreased consciousness, and seizure.Reports about brain imaging abnormality have been limited, with no pathological finding reported. The aforementioned symptoms are nonspecifically seen and do not readily lead to the correct diagnosis, which is even more difficult when symptoms in the other organs, such as cardiovascular or respiratory failure, are not apparent. The diagnosis is especially difficult in patients with chronic renal failure, since they are at risk for an increase, but not a decrease, in serum phosphate levels.We report the first patient with pathologically proven leukoencephalopathy associated with hypophosphatemia.

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