Treating Blood Cells Before Transfusion May Prevent Onset of
Blood transfusions, most often involving transfusions only of red blood cells, undoubtedly save thousands of lives each year. But when stocks of red blood cells run low, people often receive cells that have been stored for more than 30 days.

The U.S. Food and Drug Administration (FDA) allows for transfusions using blood stored for a maximum of 42 days, but recent studies have shown that cells stored for more than 30 days do not survive equally well, putting patients at risk of reduced oxygen uptake. Importantly, older red blood cells can also trigger lung hypertension....

http://pulmonaryhypertensionnews.com/2016/11/10/pulmonary-hypertension-linked-to-blood-transfusions-prevented-with-nitric-oxide-in-study
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