Treatment of acne scars with a cost-effective dermal filler
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Scarring is a frequent consequence of acne. The improvement in atrophic acne scars by dermal fillers is limited by the cost of these products. Platelet poor plasma (PPP) gel has been used as a dermal filler for the correction of facial wrinkles, tear trough deformity and recently for the boxlike scars of chickenpox.

Authors have devised a cost-effective autologous platelet-rich plasma (PRP) dermal filler gel for the correction of rolling and boxcar subtypes of soft atrophic acne scars based on the thermal denaturation and polymerization of plasma proteins. PRP is drawn into insulin syringes that are then placed in a kidney tray containing hot water at 65°C for a few minutes until the contents turn cloudy yellow indicating gel formation and its consistency was checked. The atrophic rolling and boxcar acne scars were lifted by intradermal injection of PRP gel filler resulting in a marked improvement in the appearance of atrophic scars due to tissue augmentation and remodeling of the extracellular matrix.

Though there is a solitary report of the use of PRP gel as a dermal filler for prominent nasolabial folds by aesthetic surgeons, it has not been used previously as a filler in patients with atrophic acne scars.

Tissue augmentation by PRP dermal filler gel in the case of soft atrophic acne scars not only has a volume effect with an immediate improvement in contour but may also induce remodeling of extracellular matrix by the activation of platelet-derived growth factor and various cytokines.