Trial of Amitriptyline, Topiramate, and Placebo for Pediatri
More than 6 million children and adolescents in the United States have migraines. The majority continue to have headaches into adulthood, taking a toll on the U.S. economy of approximately $36 billion and resulting in substantial effects on quality of life. Pediatric clinical practice guidelines for migraine treatment are consensus based rather than evidence based, with no Food and Drug Administration (FDA)–approved migraine prevention medication for children younger than 12 years of age....

http://www.nejm.org/doi/full/10.1056/NEJMoa1610384
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