Two Cases of Age-Related Changes in Cervical Morphology in P
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Case
The patient was a white female who visited the office for annual exams and Pap smears because of a history of prenatal DES exposure. Her gynecological history included preterm labor, premature delivery, growth retardation, and fetal distress. In her 30s and 40s, she had postcoital and intermenstrual bleeding, but workups including colposcopy showed only vaginal adenosis without dysplasia.

During the reproductive years there was no palpable or visible cervix. The cervical os appeared as a pinpoint aperture in a flattened, shallow upper vagina, bearing patchy red islands of glandular epithelium, or vaginal adenosis. Each year the upper vagina contracted and visualization of the cervical os became increasingly difficult. The patchy erythema became patchy leukoplakia. She experienced menopause at age of 49....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339519/
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