Two Genetic Regions Linked with Severe COVID-19: A genome-wi
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
There is considerable variation in disease behavior among patients infected with SARS-CoV-2, the virus that causes Covid-19. Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19.

Researchers conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, they analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels.

Results: Researchers detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level in the meta-analysis of the two case–control panels. At locus 3p21.31, the association signal spanned the genes SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6 and XCR1. The association signal at locus 9q34.2 coincided with the ABO blood group locus; in this cohort, a blood-group–specific analysis showed a higher risk in blood group A than in other blood groups and a protective effect in blood group O as compared with other blood groups.

Conclusively, Researchers identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system.

Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2020283?query=featured_home
Dr. s●●●●●i S●●●●●●●●●●●●m and 2 other likes this1 share
Like
Comment
Share