Two cases of resectable pancreatic cancer diagnosed by open
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Tumor biopsy for histological diagnosis is required preoperatively and before initiating chemotherapy or radiation therapy for patients with pancreatic cancer (Cancer of the Pancreas: Clinical Practice Guidelines, European Society for Medical Oncology). Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is widely applied to obtain tissue samples for histological examination. However, in some cases, EUS-FNA cannot be performed safely or tissue samples are insufficient to establish a definitive diagnosis. We present two cases of pancreatic cancer diagnosed by open surgical biopsy after EUS-FNA failed to yield a diagnosis.Case 1 was a 50-year-old man. Computed tomography showed a hypovascular lesion in the uncus of the pancreas.Open surgical biopsy revealed adenocarcinoma and the patient underwent preoperative chemoradiation therapy followed by curative operation. Case 2 was a 68-year-old man. Computed tomography showed a hypovascular tumor in the uncus of the pancreas. EUS revealed a 14-mm hypoechoic lesion, but EUS-FNA could not be performed because the superior mesenteric vein was located in the puncture line.Open surgical biopsy revealed adenocarcinoma and the patient underwent preoperative chemoradiation therapy followed by pancreaticoduodenectomy...

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