Two thirds of COVID-19 patients improve after Gilead drug
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More than two-thirds of severely ill COVID-19 patients saw their condition improve after treatment with remdesivir, an experimental drug being developed by Gilead Sciences Inc., according to a study published by the New England Journal of Medicine.

The paper’s author called the findings “hopeful,” but cautioned that it is difficult to interpret the results since they do not include comparison to a control group, as would be the case in a randomized clinical trial. In addition, the patient numbers were small, the details being disclosed are limited, and the follow-up time was relatively short.

Gilead last month sharply limited its compassionate use program for remdesivir and is conducting its own clinical trials of the antiviral drug, with results expected in the coming weeks. Researchers in China, as well as the U.S. National Institutes of Health, are also testing the drug in COVID-19 patients.

The new analysis includes patients in the United States, Europe, Canada and Japan who received a 10-day course of intravenous remdesivir.

Before the treatment, 30 patients were on mechanical ventilators, and four were on a machine that pumps blood from the patient’s body through an artificial oxygenator. After a median follow-up of 18 days, 36 patients, or 68%, had an improvement in oxygen-support class, including more than half of the 30 patients receiving mechanical ventilation who had their breathing tubes removed. A total of 25 patients, or 47%, were discharged from the hospital. Seven patients, 13% of the total, died.

Twelve patients, 23%, had serious side effects including multiple-organ-dysfunction syndrome, septic shock and acute kidney injury.

“We look forward to the results of controlled clinical trials to potentially validate these findings,” wrote Dr. Jonathan Grein, the paper’s lead author and director of hospital epidemiology at Cedars-Sinai Medical Center, Los Angeles.

Source: https://in.reuters.com/article/health-coronavirus-gilead-remdesivir/two-thirds-of-covid-19-patients-improve-after-gilead-drug-nejm-idINKCN21T05L
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