Type 2 Diabetes Linked to Increased Risk for Parkinson's
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New analyses of both observational and genetic data have provided "convincing evidence" that type 2 diabetes is associated with an increased risk for Parkinson's disease.

The objective was to investigate T2DM as a determinant of PD through a meta-analysis of observational and genetic summary data.

A systematic review and meta-analysis of observational studies was undertaken by searching 6 databases. Researchers selected the highest-quality studies investigating the association of T2DM with PD risk and progression. They then used Mendelian randomization (MR) to investigate the causal effects of genetic liability toward T2DM on PD risk and progression, using summary data derived from genome-wide association studies.

Results:
-- In the observational part of the study, pooled effect estimates showed that T2DM was associated with an increased risk of PD, and there was some evidence that T2DM was associated with faster progression of motor symptoms and cognitive decline.

-- Using MR, they found supportive evidence for a causal effect of diabetes on PD risk and some evidence of an effect on motor progression but not on cognitive progression.

Conclusively, using meta-analyses of traditional observational studies and genetic data, researchers observed convincing evidence for an effect of T2DM on PD risk and new evidence to support a role in PD progression.

Source: https://movementdisorders.onlinelibrary.wiley.com/doi/full/10.1002/mds.28551
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