Type 2 diabetes and Change in Total Hip Bone Area and Bone M
In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with a greater bone mineral density (BMD) at the total hip.

This study aimed to investigate these associations longitudinally, by studying T2DM status (no T2DM n=1521, incident T2DM n=119 or prevalent T2DM n=106) in relation to changes in total hip bone area and BMD.

In three cohorts, the Swedish Mammography Cohort Clinical (SMCC; n=1060, Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n=483) and Uppsala Longitudinal Study of Adult Men (ULSAM; n=203), with repeat assessment of T2DM status and dual energy x-ray absorptiometry (DXA) measurements of total hip bone area and BMD on average 8 years apart, a linear regression model was used to assess the effect of T2DM status on change in bone area and BMD at the total hip.

Results:
-- After meta-analysis, the change in bone area at the total hip was 0.5% lower among those with incident T2DM compared to those without T2DM.

-- The change in bone area was similar among those with prevalent T2DM compared to those without.

-- For BMD, the combined estimate was 0.004 g/cm 2 among those with incident T2DM and 0.010 g/cm 2 among those with prevalent T2DM, compared to those without T2DM.

Conclusively, those with incident T2DM have a lower expansion in bone area at the total hip compared to those without T2DM.

Source: https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab490/6313244?rss=1
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