UWF SS OCTA: A Diagnostic method used in Diabetic Eyes to de
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A Study was conducted to investigate the alterations in retinal microvasculature in eyes with preclinical diabetic retinopathy (DR) using ultra-wide field swept-source optical coherence tomography angiography (UWF SS OCTA).

A total of 55 eyes from 30 diabetic patients with no clinical retinal signs were studied. To create a UWF OCTA image, all subjects underwent OCTA examination with a 12 12 mm2 field of view and 5 visual fixations (1 central fixation and 4 peripheral fixations). The central area in the UWF images corresponded to the original central image obtained using central fixation, and the peripheral area was the rest of the image. In different areas, lesions such as nonperfusion areas (NPAs), microvascular dilation and tortuosity, and neovascularization (NV) were reported. It was also noted that the patient had a history of diabetes.

Results:
--Peripheral areas presented significantly more microvascular dilation and tortuosity than central areas and more NPAs than central areas, with borderline significance.
--The number of lesion types was associated with HbA1c levels in the peripheral and overall areas.

To summarize, UWF SS OCTA is a promising imaging tool for detecting vascular alterations in diabetic eyes without clinical signs and revealing retinal microvascular alterations in diabetic eyes without clinical signs. These changes were linked to a variety of structural conditions.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01933-3
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