Ulipristal acetate before in vitro fertilization: efficacy i
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
The presence of submucous fibroids strongly impacts on IVF results, therefore, these patients should be considered for surgical or medical treatment. The aim of this study was to assess the role of Ulipristal acetate (UPA), a selective progesterone receptor modulator, in restoring uterine cavity deformation due to submucous fibroids, in infertile patients attempting an IVF treatment. The secondary study outcome was to evaluate the impact of preconception UPA treatment on rate of biochemical pregnancy, ongoing pregnancy, and live birth compared to a control group without fibroids.

Infertile patients with submucosal fibroid (Type 1 and Type 2 according to FIGO classification) were enrolled in the study as fibroids group and received 1 to 3 treatment cycles of UPA, according to their response, as reflected by fibroid volume reduction and restoration of normal uterine cavity. Twenty-six patients underwent UPA treatment revealed a mean volume reduction of their fibroids of 41%. A total of 15 (57.6%) biochemical pregnancy were obtained, resulting in 13 (50%) ongoing pregnancy and 9 (34.6%) healthy babies were already delivered. Similar results were obtained in control group.

In conclusion, the presence of submucous fibroids strongly impacts on IVF results, therefore, this patient should be considered for surgical or medical treatment. UPA therapy is efficient in restoring uterine cavity deformation and improving subsequent IVF outcome. Avoiding surgery is also crucial in infertile women. Further large randomized controlled studies are needed to confirm observation and to further define patient selection criteria. These will aid both fertility specialists’ counseling and their patients in tailoring the correct approach to the submucosal fibroid, optimizing the results without losing time.

Source:https://rbej.biomedcentral.com/articles/10.1186/s12958-020-00611-1
Like
Comment
Share