Ultrawide-field fundus photography used for detecting retina
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Evaluation of the retinal nerve fibre layer (RNFL) is important for identifying glaucomatous damage. Ultrawide-field fundus photography (UWP) imaging is increasingly used in the ophthalmological field for the same.

Researchers investigated whether RNFLD can be detected with UWP images and compared the clinical effectiveness of three types of images for detecting RNFLD: conventional red-free RNFL photography (RFP), non-mydriatic UWP and digitally converted green separation of non-mydriatic UWP (G-UWP).

Eyes with glaucoma or glaucoma suspects, as well as regular control eyes that met the eligibility requirements, were all enrolled in the study at the same time. To determine the sensitivity and specificity for detecting RNFLD, their traditional RFP, non-mydriatic UWP, and G-UWP images were evaluated.

Results:
--Three image sets of 196 participants (84 normal control, 25 glaucoma suspect and 87 glaucoma) were obtained.

--The sensitivity of G-UWP (94.6%) and RFP (92.9%) was higher than that of UWP (82.1%).

--The sensitivities of G-UWP and RFP are comparable. The specificity of G-UWP (78.6%) and UWP (75.0%) was comparable, but both were lower than that of RFP (98.8%).

Finally, RNFLD can be detected using non-mydriatic UWP images. Non-mydriatic G-UWP had a similar sensitivity to traditional RFP but a lower specificity. In clinical settings, non-mydriatic G-UWP may be a safe and valuable diagnostic method for glaucoma screening.

Source: https://bjo.bmj.com/content/early/2021/05/18/bjophthalmol-2020-318559?rss=1
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