Unrecognized Interstitial Lung Disease as a Result of Chroni
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Background
Drug-induced interstitial lung disease is a rare condition attributed to several medications, including antimicrobial agents such as amphotericin B, anti-inflammatory agents such as methotrexate, biologic agents such as bevacizumab, and cardiovascular agents and chemotherapeutic agents. The current Infectious Diseases Society of America and European Society of Microbiology and Infectious Diseases guidelines recommend nitrofurantoin as a first-line medication for the treatment of uncomplicated cystitis and suppression of recurrent urinary tract infections, a common problem prevalent in females. The classic presentation of interstitial lung disease usually occurs within 3–8 days of starting nitrofurantoin, but may occur a few hours to 4 weeks after the first dose. Confirmatory diagnosis is based on clinical imaging and histopathology, documentation of drug exposure, improvement after discontinuing the agent, and symptom onset following a rechallenge with the offending agent. We report a case of interstitial lung disease as a result of chronic exposure to nitrofurantoin, as well as a review of the current literature....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078134/
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