Unusually very late-onset new growth of intraocular retinobl
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Retinoblastoma is the most common primary ocular malignancy of early childhood and it represents about 4% of childhood cancer and less than 1% of all human cancers. The malignancy can occur in one or both eyes and may be either unifocal or multifocal. All bilateral retinoblastoma are hereditary while only 10–15% of unilateral retinoblastomas are hereditary. A 12-year-old monoophthalmic female patient presented with bilateral familial retinoblastoma showing new growth of intraocular tumor after 11 years of complete regression following combined local and systemic treatments. The new tumor growth was treated with diode laser transpupillary thermotherapy, ruthenium-106 plaque radiotherapy and adjuvant intravenous chemotherapy and the tumor regressed.

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