Up to 45 percent of COVID-19 infections may be asymptomatic:
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45 percent of people infected by the virus behind the ongoing deadly COVID-19 pandemic, never show symptoms of the disease, according to the results of a Scripps Research analysis of public datasets on asymptomatic infections.

The findings from the study recently published in Annals of Internal Medicine, suggests:

• Asymptomatic infections may have played a significant role in the early and ongoing spread of COVID-19.

• Researchers highlight the need for expansive testing and contact tracing to mitigate the pandemic.

• Among more than 3,000 prison inmates in four states who tested positive for the coronavirus, the figure was astronomical: 96 percent asymptomatic

• The review further suggests that asymptomatic individuals are able to transmit the virus for an extended period of time, perhaps longer than 14 days.

• CT scans conducted on 54 percent of 76 asymptomatic individuals on the Diamond Princess cruise ship, appear to show significant subclinical lung abnormalities raising the possibility of SARS-CoV-2 infection impacting lung function that might not be immediately apparent.

Source: https://neurosciencenews.com/asymptomatic-coronavirus-16534/
Dr. S●●●●●●●●i K●●●●●o and 2 other likes this2 shares
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Dr. V●●●j S●●●●●a
Dr. V●●●j S●●●●●a Pharmacology
Apparently if one is asymptomatic one has a low viral load. So when an RT-PCR is done it generally turns out to be negative. Perhaps this is the reason why ICMR initially recommended testing of only those who were symptomatic. But if asymptomatic people have a low viral load, then how do they become positive on RT-PCR? So when we say up to 45\% of cases are asymptomatic, the paradox is how do they become positive on RT-PCR? Unless RT-PCR is so sensitive that it can pick up the viral RNA even if the viral load is very low, e.g., in asymptomatic infected people. Infection, per Ananthanarayan’s textbook of microbiology, only means the microorganism has entered and lodged in or on our tissues and has started multiplying. It is still not disease. Once the organism breaches cell membrane integrity and provokes our immune system to respond or react, that is when we become symptomatic. In the case of this virus, replication happens when the virus enters the intracellular endosome.... Read more
Jun 14, 2020Like1
Dr. N●●●●a G●●●a
Dr. N●●●●a G●●●a Obstetrics and Gynaecology
True, a person with low viral load will spread the disease and those with low immunity and comorbidities will be seriously affected, hence herd immunity and robust treatment modalities is the only solution to handle the pandemic of this magnitude, testing will be effective in making the containment zones.
Jun 15, 2020Like