Urinary sodium-to-potassium ratio associates with hypertensi
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
A cross-sectional study was performed to clarify the associations between salt load index (urinary sodium-to-potassium ratio (Na/K ratio)), current disease activity, and hypertension in an RA population.

The Kurama cohort database yielded a total of 336 participants. The spot urine Na/K ratio was used as a simplified index of salt loading, and the 28-joint RA Disease Activity Score (DAS28-ESR) was used as a measure of current RA disease activity. Using these measurements, researchers looked at statistical associations between urinary Na/K ratio, DAS28-ESR, and hypertension prevalence.

Results:
--Urinary Na/K ratio was positively associated with measured systolic and diastolic blood pressure and also with prevalence of hypertension even after covariate adjustment (OR 1.34).

--In addition, increased urinary Na/K ratio was significantly and positively correlated with DAS28-ESR in multiple regression analysis (estimate 0.12), as was also the case in gender-separated and prednisolone-separated sub-analyses.

In RA patients, the urinary Na/K ratio was related to current disease activity as well as the prevalence of hypertension. As a result, dietary changes like salt restriction and potassium supplementation should be looked into as a possible candidate for reducing both disease activity and hypertension in RA patients.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02479-x
Like
Comment
Share