Use of Cenegermin in the Presence of Bandage Contact Lenses
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The aim of this study was to characterize the outcomes of eyes with neurotrophic keratitis (NK) treated with a course of cenegermin-bkbj in the presence of a bandage contact lens (BCL).

A retrospective chart review of all eyes with a clinical diagnosis of NK treated with cenegermin-bkbj was performed. Inclusion criteria included cenegermin-bkbj treatment with a BCL in place. Demographics, etiology, visual acuity, pretreatment and posttreatment corneal sensation, and treatment outcomes were assessed.

Results:
--There were 18 eyes of 16 patients with NK treated with cenegermin-bkbj while having a BCL in place.

--After cenegermin-bkbj treatment, presence of corneal sensation significantly increased from 7% of eyes to 79% of eyes.

--There was also a significant increase in the number of quadrants with corneal sensation.

--6 of 10 eyes with a persistent epithelial defect (PED) experienced complete resolution at the conclusion of treatment, while 3 additional eyes experienced a decrease in the defect size.

--Despite all 18 eyes necessitating a chronic BCL before cenegermin-bkbj treatment, 4 were able to maintain their epithelium without a BCL after treatment for at least some period.

Finally, Cenegermin-bkbj treatment for NK with BCL showed an improvement in the feeling of the cornea, the extent of epithelial defects and fluorescent stain. In eyes showing past decompensation of the ocular surface by termination of BCL, maintenance of usage of BCL may be taken into consideration while using cenegermin-bkbj.

Source: https://journals.lww.com/corneajrnl/Abstract/9000/Use_of_Cenegermin_in_the_Presence_of_Bandage.95714.aspx
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