Use of Dexamethasone/Netilmicin Fixed Combination in Control
A Study was conducted to evaluate the short-term anti-inflammatory effect of dexamethasone/netilmicin fixed combination in the management of ocular inflammation after cataract surgery.

238 patients were randomized 2:1 to dexamethasone/netilmicin (dexa/net, n=158) or betamethasone/chloramphenicol (beta/chl, n=80). Treatment started on the day of surgery and continued 4 times daily for 7 days.

The primary efficacy parameter was the anterior chamber (AC) flare. The percentage of patients displaying none or mild AC flare was defined as “efficacy rate”, whereas the percentage of patients showing a decrease of AC flare score from baseline was defined as “percentage of responders”. Dexa/net was considered effective if the efficacy rate was not inferior to that of beta/chl.

Results:

--After 7 days of treatment, no AC flare was observed in 92.8% (dexa/net) and 92.3% (beta/chl) of patients, whereas no AC cells were observed in 91.5% (dexa/net) and 93.6% (beta/chl) of patients, respectively.

--The “efficacy rate” was 100% in both groups, whereas the “percentage of responders” was 94.1% in the dexa/net and 93.6% in the beta/chl group.

--Other efficacy parameters confirmed both treatments as highly effective, despite their difference in steroid content (2 mg/mL for beta/chl vs 1 mg/mL for dexa/net).

--IOP and visual acuity at the end of the study were comparable. Two cases of allergic conjunctivitis were considered adverse events and were both related to dexa/net.

The short term application of dexa / net fixed combination, after an uncomplicated cataract operation, is safe and effective in the treatment of post-operational inflammation.

Source: https://www.dovepress.com/short-term-use-of-dexamethasonenetilmicin-fixed-combination-in-control-peer-reviewed-fulltext-article-OPTH
Like
Comment
Share