Use of a combination of N-acetylcysteine and clonazepam to t
A combination of N-acetylcysteine (NAC) and clonazepam is efficacious for the treatment of burning mouth syndrome (BMS).

This study was intended to evaluate the clinical efficacy of a combination of N-acetylcysteine (NAC) and clonazepam for the treatment of burning mouth syndrome (BMS). The study was published in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology.

A total of 160 BMS patients were divided into three groups: Group I received NAC (400 mg/day), Group II, clonazepam (0.5 mg/day), and Group III, both NAC and clonazepam. Investigators evaluated symptom relief after 8 weeks of treatment using a visual analog scale (VAS).

- The overall response rates of the three groups were 60.3%, 51.3%, and 80.0%, respectively.

- The mean VAS and OHIP-14K scores significantly decreased in all groups after the 8-week treatments. The VAS score changes were -12.2 ± 19.5, -10.0 ± 14.1, and -21.0 ± 24.6, respectively, in the three groups and the OHIP-14K changes were -2.3 ± 9.2, -4.4 ± 6.9, and -8.7 ± 10.3, respectively.

- Group III showed significantly larger differences in VAS and OHIP-14K scores than that of Group II before and after treatment.

In the treatment of BMS, the NAC/clonazepam combination therapy was more effective than either monotherapy.

Source: https://doi.org/10.1016/j.oooo.2021.07.016
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