Uveitis screening should begin immediately after JIA diagnos
This prospective study reports the long-term outcomes of uveitis among children with juvenile idiopathic arthritis (JIA).

Researchers from 12 centers across Denmark, Finland, Norway, and Sweden followed 434 patients with juvenile idiopathic arthritis for 18 years. Outcomes included a diagnosis of uveitis, use of systemic immunosuppressive therapy, ocular complications, and visual acuity.

By the end of the study, more than 20% of patients developed uveitis, and most were diagnosed with uveitis within the first 8 years of juvenile idiopathic arthritis diagnosis; however, a small percentage of patients developed uveitis after 8 years. A short duration between each diagnosis increased the risk of developing ocular complications. All patients diagnosed with uveitis prior to juvenile idiopathic arthritis developed cataracts and were at high risk for developing glaucoma (OR 31.5). Children with uveitis were more likely to be on systemic immunosuppressive medication.

Approximately a quarter of patients with newly diagnosed juvenile idiopathic arthritis will also have uveitis. Ocular complications are more common if uveitis develops either before or soon after juvenile idiopathic arthritis diagnosis. Early systemic immunosuppression can help mitigate the risk of ocular complications from juvenile idiopathic arthritis-associated uveitis.