Various Peaks of Circumpapillary Retinal Nerve Fibre layer a
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
A Study was conducted to investigate the distribution and associations of the circumpapillary retinal nerve fibre layer thickness (RNFLT) profile, characterised as peak height and peak position, in healthy eyes.

667 healthy participants were randomly selected. RNFLT was measured at 768 points at 3.4 mm circumpapillary position using spectral-domain optical coherence tomography (OCT). The location and height of the superior temporally peak (PeakST), superior nasal peak (PeakSN) and inferior temporal peak (PeakIT) were assessed.

Results:
--The RNFLT was thickest at PeakIT (194±25 microm; location: 288±12°), followed by PeakST (182±25 microm; 73±10°) and PeakSN (125±23 microm; 135°±13°).

--In multivariable analysis, peak RNFLT decreased with longer axial length, older age (beta: -0.10; PeakST and PeakIT), female gender (beta: -0.09; PeakST), and larger parapapillary gamma zone and beta zone width (beta: -0.16 to -0.11; PeakSN).

--The temporal peaks were located more closely to the horizontal line in women (beta: 0.09–0.11) and with longer axial length (beta: 0.27–0.31), while they were located more inferiorly in eyes with larger Bruch’s membrane openings (BMOs) (beta:0.10-0.11).

Finally, Peak RNFLT shrank by 0.34 microm for each year of age (PeakST and PeakIT), 3.2–3.5 microm for each 1 mm rise in axial length (all three peaks), and was 4.5 microm thinner in women than men. Sex, axial length, and BMO diameter all influenced the location of temporal peaks. These associations should be considered in OCT-based RNFLT disease detection, especially in glaucoma evaluation.

Source: https://bjo.bmj.com/content/early/2021/04/14/bjophthalmol-2021-318869?rss=1
Like
Comment
Share