Vasculitic Central Retinal Vein Occlusion: The Presenting Si
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Rheumatoid arthritis (RA) is estimated to affect 0.8% of the world's population, making it the most common inflammatory arthritis. It is characterized by a painful, persistent, and often symmetrical polyarthritis that primarily involves the synovial tissues. Additionally, RA can be categorized and broadly divided into two categories based on serology: seropositive RA and seronegative RA. Approximately 40% of seropositive RA patients experience extra-articular involvement of multiple organ systems, including the eyes. Less is known about seronegative RA and its extra-articular features, but generally speaking seronegative RA is felt to be less aggressive, with fewer joint erosions and better response to treatment than seropositive RA. The ophthalmic sequelae of RA vary widely and range from relatively benign findings, such as keratoconjunctivitis sicca and episcleritis, to serious vision-threatening conditions, including anterior scleritis, necrotizing scleritis, scleromalacia perforans, peripheral ulcerative keratitis and retinal vasculitis secondary to posterior scleritis.

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