Vaspin is associated with CV risk factors that may affect th
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Vaspin is an anti-inflammatory adipokine that has been linked to CV disease and inflammation in chronic inflammatory conditions other than axial spondyloarthritis (axSpA). The aim of the study was to see how vaspin affected subclinical atherosclerosis and CV risk in axSpA on a genetic and serological level.

This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA® v.11.1.

Results:
--Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight.

--At the genetic level, it was disclosed that the minor allele of rs2236242 (A) was associated with lower serum vaspin levels in axSpA, while the rs7159023 minor allele (A) was linked to higher serum levels.

--When the three polymorphisms assessed were combined conforming haplotypes, TGC haplotype was related to high serum levels of vaspin.

--However, no statistically significant association was observed between vaspin and markers of subclinical atherosclerosis, both at the genetic and serological level.

In conclusion, these findings show that vaspin is associated with CV risk factors that may affect the atherosclerotic process in axSpA. In a broad cohort of patients with axSpA, serum vaspin concentration is also genetically modulated.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02499-7
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