Venous Thromboembolism in Pediatric Inflammatory Bowel Disea
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Inflammatory bowel disease (IBD) is associated with increased risk of venous thromboembolism (VTE). The objectives of this study were to characterize pediatric IBD patients with VTE and determine risk factors.

This was a nested case-control study comparing hospitalized children with IBD diagnosed with VTE to those without VTE over a decade at a large referral center. Standard descriptive statistics were used to describe the VTE group. Multivariable conditional logistic regression was used to assess risk factors.

Results:
--23 cases were identified. Central venous catheter (CVC) presence (odds ratio [OR] 77.9) and steroid use (OR 12.7) were independent risk factors.

--Median age at VTE was 17 years (interquartile range [IQR] 13.5--18.2), and in 48%, VTE was the indication for admission.

--Median duration of anticoagulation was 3.8 months (IQR 2.3--7.6), and there were no major bleeding events for patients on anticoagulation.

--There were no patients with known sequelae from VTE, though 22% had severe VTE that required interventions.

In conclusion, VTE is a concern for pediatric patients with IBD, but the absolute risk remains low. The safety and efficacy of pharmacologic thromboprophylaxis in this population should be further investigated, with a focus on risk factors including steroid use and the presence of CVC.

Source: https://journals.lww.com/jpgn/Abstract/2021/05000/Venous_Thromboembolism_in_Pediatric_Inflammatory.24.aspx
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