Venous thromboembolism in lung transplant recipients
Venous thromboembolism (VTE) post-lung transplantation is common and has been associated with worse post-transplant survival.

Researchers report a comprehensive single-center review of VTE incidence in the first post-transplant year, investigate modifiable risk factors and assess the impact on short-term outcomes.

A retrospective review of all lung transplant recipients was carried out. Patients were followed for one-year post-transplant. All patients were screened for deep venous thrombosis (DVT) within the first two weeks with a venous duplex study. Pre-transplant, intraoperative, post-operative variables, and peri-operative practice patterns were compared between VTE positive and VTE negative groups.

- 235 patients were included in the study, 58 patients developed a VTE in the first post-transplant year. The median time to diagnosis was 17 days.

- Of the patients with VTE, 76% had an isolated DVT, 13.5 % had an isolated pulmonary embolism (PE), and 10.3% had concomitant DVT and PE.

- In a multivariate logistic regression model, cardiopulmonary bypass (CPB) and interruption of VTE prophylaxis were predictive of early VTE.

In particular, VTE post-lung transplant is common despite the use of prophylactic anticoagulation. CPB use and interruption of DVT prophylaxis are risk factors for early post-transplant VTE.

The Journal of Heart and Lung Transplantation