Vienna researchers explore a new way of specific drug delive
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As per the study published in Nanomedicine-Nanotechnology, Biology, and Medicine, researchers from the Medical University of Vienna have shown a straightforward method to functionalize liposomes for specific targeting, potentially paving the way for personalized medicine.

They found a smart and easy way for liposome functionalization: by linking the small specific fragment of the antibody, called Fab, by gene technology with a hydrophobic anchor through which the Fab fragment got naturally inserted into the hydrophobic liposomal membrane part during liposomal preparation. specific targeting was observed not only in the antigen-positive cells in the lab dish but also in mice, where liposomes precisely recognized human tumors that the researchers had implanted. If this method is coupled with the screening of patient's tumors for the presence of a unique surface protein, which can be targeted with the Fab fragment-functionalized liposomes, then there is a possibility of treating tumors more efficiently and decrease the side effects of the delivered anti-cancer drugs substantially...

http://www.nanomedjournal.com/article/S1549-9634(17)30170-3/fulltext
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