Vismodegib dose reduction effective when combined with itrac
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Case 1: An 84 year old man was seen for a BCC of the left chin that recurred 2 years after Mohs micrographic surgery. He presented with a large, fixed, ulcerated, firm tumor. (MRI) showed the tumor approximating the bone. Patient refused surgery given his age and the possibility of an extensive surgical intervention and was placed on vismodegib 150 mg once per week and itraconazole 200 mg per day.

Notable clinical improvement was observed after 4 weeks of treatment. After 12 weeks, the area was completely healed, and the tissue was more supple. He continued the medications for a total of 28 weeks. His last follow up was 16 months after the initiation of treatment, and there was no clinical evidence of tumor progression. This patient experienced body hair loss and muscle spasms of the legs which was described as mild and tolerable. There were no laboratory abnormalities throughout treatment.

Case 2: An 85 year old man presented for Mohs micrographic surgery for a large scabbed BCC on his right ear. He was concerned about the of risk deformity and asked for an alternative treatment. He was placed on vismodegib 150 mg twice a week (Mondays and Fridays) and itraconazole 100 mg per day. There was significant clinical improvement after 8 weeks of treatment. At 16 weeks, the ear was healed. His total treatment duration was 21 weeks. At his last follow up at 16 months after the initiation of the combination therapy, there was no clinical evidence of tumor regrowth.

Source: https://www.jaadcasereports.org/article/S2352-5126(20)30809-2/fulltext?rss=yes
Like
Comment
Share