Vitamin D Reduces Risk Of Kidney Cancer, Finds Study
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This meta-analysis is the first to evaluate the associations of circulating and dietary intake of vitamin D with risk of risk of renal cell carcinoma (RCC). The findings showed that higher circulating vitamin D level and dietary vitamin D intake were associated with a reduced risk of RCC. The possible explanation might be attributed to the anti-inflammatory effect, inhibiting cell proliferation, inducing cell differentiation and apoptosis.

Researchers searched the MEDLINE, EMBASE, and Scopus databases from for observational studies. The pooled relative risks (RRs) with corresponding 95% CIs were calculated using random-effects or fixed-effects models. The Newcastle-Ottawa scale was employed to assess the quality of the included studies.

Results:
-- A total of 9 publications were included in this meta-analysis. An overall analysis of the highest versus lowest intake levels revealed that circulating vitamin D level was protectively associated with risk of RCC 0.76, with no evidence of heterogeneity.

-- In addition, dietary vitamin D intake was associated with a reduced risk of RCC.

-- Statistical heterogeneity was not identified. Subgroup analyses results showed the gender differences, and the associations were significant in results with women participants and case-control studies.

Conclusively, higher circulating vitamin D level and higher dietary vitamin D intake both might be associated with a reduced risk of RCC. Further high-quality randomized controlled trials are required in the future to confirm our results.

Source: https://pubmed.ncbi.nlm.nih.gov/33146974/
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