Vitamin D deficiency may lead to pain in Postmenopausal wome
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A Study was conducted to investigate the impact of vitamin D levels on early clinical function outcomes and the potential risk factors of moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty (TKA).

A total of 226 women were hired retrospectively. Based on their preoperative serum 25-hydroxyvitamin D levels, the women were divided into two groups: (1) vitamin D-sufficient (more than 30 ng/mL) and (2) vitamin D-deficient (less than 30 ng/mL).

The visual analog scale, Western Ontario and McMaster Arthritis Index score, and Knee Society Score were used to evaluate clinical outcomes. Risk factors for developing postoperative moderate-to-severe knee pain were studied using multivariate binary logistic regression analyses.

Results:
--There was no significant difference in preoperative clinical function assessment between the two groups. The difference in postoperative Western Ontario and McMaster Arthritis Index score between the two groups was statistically significant.

--However, the differences in postoperative visual analog scale and Knee Society Score scores between the two groups were not significant.

--The incidence of postoperative moderate-to-severe pain was 16.4%.

--Multivariate logistic regression analysis revealed that vitamin D deficiency, smoking, and high body mass index were potential risk factors for moderate-to-severe knee pain in postmenopausal women early after TKA.

Finally, early functional results in postmenopausal women after TKA may be harmed by preoperative vitamin D deficiency. Furthermore, vitamin D deficiency, smoking, and a high BMI were all found to be independent risk factors for moderate-to-severe knee pain following surgery.

Source: https://journals.lww.com/menopausejournal/pages/articleviewer.aspx?year=9000&issue=00000&article=96966&type=Abstract
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