Vitamin D receptor expression in uterine leiomyoma and nonne
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Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, including intense bleeding, compression of adjacent organs, pain, and infertility. Studies show that vitamin D receptor (VDR) expression is correlated with the etiology of uterine leiomyomas.

This study aimed to assess the expression of VDR in uterine leiomyoma and nonneoplastic myometrial tissue. It was published in Reproductive Biology and Endocrinology.

A controlled cross-sectional study involving 40 women who underwent an abdominal hysterectomy, was performed to compare the immunohistochemical expression of VDR in samples of uterine leiomyoma tissue with adjacent nonneoplastic myometrial tissue. The mean percentages of stained nuclei in the two groups were compared by Student’s t teste, with significance established at p?<?0.05.

The percentage of cells with nuclei stained by anti-VDR in the myometrial and leiomyoma tissue was 79.52?% and 60.22?%, respectively.

Conclusively, the mean percentage of nuclei expressing VDR was significantly lower in the uterine leiomyoma than in nonneoplastic myometrial tissue.

Source: https://doi.org/10.1186/s12958-021-00752-x
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